Molecular mechanisms of transcriptional regulation in yeast.

PERSPECTIVE AND SUMMARY ................................................................ 1051 YEAST PROMOTER ELEMENTS ................................................................ 1052 SPECIFIC DNA-BINDING PROTEINS .......................................................... 1054 TRANSCRIPTIONAL ACTIVATION ............................................................ 1059 REGULATION ........................................................................................ 1062 MORE CO~vlPLEX PHENOMENA ............................................................... 1063 Multiple Proteins Recognizing the Same Target Sequence ............................... 1063 Multiple Proteins Necessary for a Single DNA-Binding Event .......................... 1065 Multiple Proteins Necessary for Activation or Repression ................................ 1066 Activation and Repression by the Same Protein ............................................ 1067 Functional Distinctions Between TATA Elements ........................................... 1068 Poly(dA-dT) Sequences and the Effect of Chromatin ...................................... 1069 Upstream Activator Proteins Function When Bound at the TATA Position ........... 1070 MOLECULAR MECHANISM OF ACTIVATION AND REPRESSION .................. 1070 EVOLUTION .......................................................................................... 1073